| abstract |
The subject of the invention is a method for detecting irreversible DNA damage, characterized in that it comprises the following steps: - obtaining a suspension of isolated cells by dissociation of a multicellular system, - recovery and treatment of the cells, and measuring the level of micronuclei formed in the cells. The invention relates more particularly to a method for measuring the genotoxic effects of compounds, as well as its uses, in particular for the detection, analysis and / or study of the toxicity of compounds to humans or the environment, or to the evaluation of the therapeutic efficacy of compounds, in particular for the evaluation of the efficacy of chemotherapeutic substances or anti-cancer substances or for the evaluation of the effectiveness of water treatment processes or sludge. |