| abstract |
The invention relates to hexafluoroisopropyl carbamate derivatives of general formula (I) wherein R represents a group R optionally substituted with one or more R and / or R groups; R represents an aryl or heteroaryl group; R represents a halogen atom or a cyano, nitro, oxo, (C -C) alkyl, (C -C) alkoxy, hydroxyl, (C -C) alkylthio, (C -C) haloalkyl, (C -C ) haloalkoxy, (C -C) haloalkylthio, NR R, NR COR, NR SO R, COR, CO R, CONR R, SO R, SO NR R, phenyloxy or benzyloxy; R represents a monocyclic aryl or heteroaryl group; Z represents a bond, a (C -C) alkylene group, a (C -C) alkenylene group, a (C -C) alkynylene group, an O- (C -C) alkylene group, a N (R) group - (C -C) alkylene; A represents a bond, an oxygen atom, a sulfur atom, a N (R), N (R) - (C -C) alkylene group, a CON (R) group, a CON (R) - ( C -C) alkylene, a SO N (R) group, a SO N (R) - (C -C) alkylene group, an OCON (R) group, an OCON (R) - (C -C) alkylene group, a group N (R) CON (R), a group N (R) CON (R) - (C -C) alkylene, a group N (R) SO N (R), a group N (R) SO N ( R) - (C -C) alkylene, O- (C -C) alkylene, N (R) CO, N (R) CO - (C -C) alkylene, S- (C) -C) alkylene, a group SO, a group SO - (C -C) alkylene, a group N (R) SO, a group N (R) SO - (C -C) alkylene, a group CO, a group CO - (C -C) alkylene, a group N (R) CO, a group N (R) CO- (C -C) alkylene, a group SO N (R) CO, a group SO N (R) CO- ( C -C) alkylene, a group SO N (R) CON (R), a group SO N (R) CON (R) - (C -C) alkylene; R and R represent independently of each other a hydrogen atom, a (C -C) alkyl group; m and n represent, independently of each other, an integer of 0 or 1, in the form of a base or an addition salt with an acid. Preparation process and therapeutic application |