| abstract |
The invention relates to a targeting agent to which at least one cryptophycin derivative of formula (I) is attached: in which: R represents a halogen atom and R represents an -OH group, an acyl group derived from an amino acid AA or a (C -C) alkanoyloxy group; or R and R together form an epoxy unit; • AA means a natural or unnatural amino acid; R represents a (C -C) alkyl group; R and R are both H or together form a CH = CH double bond between C13 and C14; R and R represent independently of each other H or a (C -C) alkyl group; R and R represent independently of each other H or a (C -C) alkyl group; R represents at least one substituent of the phenyl ring selected from: H, an OH, (C -C) alkoxy group, a halogen atom; R represents at least one substituent of the phenyl ring selected from H or a (C -C) alkyl group; the targeting agent and the cryptophycin derivative being covalently attached, the attachment being in the ortho (o), meta (m) or para (p) position of the phenyl ring bearing the CR unit. |