| abstract |
The invention relates to compounds of formula (I): ## STR1 ## in which A represents a link an oxygen atom or a group -O-CH 2 -; Ar 1 represents phenyl or heteroaryl; Ar 2 represents phenyl, heteroaryl or heterocycloalkyl; R1a, b, c and R2a, b, c, each represents a hydrogen or halogen atom or an alkyl, cycloalkyl, -OR5 (hydroxy or alkoxy), hydroxy-alkyl, alkoxy-alkyl, alkoxy-alkoxy, haloalkyl , -O-haloalkyl, oxo, -CO-alkyl, -CO-alkyl-NR6R7, -CO-haloalkyl, -COOR5, alkyl-COOR5, -O-alkyl-COOR5, -SO2-alkyl, -SO2-cycloalkyl, - SO2-alkyl-cycloalkyl, -SO2-alkyl-OR5-SO2-alkyl-COOR5, -SO2-alkyl-NR6R7-SO2-haloalkyl, alkyl-SO2-alkyl, -SO2-NR6R7, -SO2-alkyl-O-alkyl- OR5, -CONR6R7, -alkyl-CONR6R7 or -O-alkyl-NR6R7, or R1a, R1b, R1c are respectively bonded to R2a, R 2b, R 2c and the carbon atom that carries them and represent -O- alkyl-O-; R3 represents a hydrogen atom or an alkyl, R4 represents a hydrogen or halogen atom or a cyano, -OR5, hydroxy-alkyl, -COOR5, -NR6R7, -CONR6R7, -SO2-alkyl, -SO2- NR6R7, -NR6-COOR5 or -CO-NR6-alkyl-OR5; R5, R6 and R7 each represents a hydrogen atom, an alkyl or an alkylphenyl, and R8 represents a hydrogen atom, an -SO2-alkyl or a group of formula -B-Het, where B may be absent or represent a bond, an oxygen atom or -CO- or -SO2- (CH2) n with n equal to 0, 1 or 2 and where Het represents a heteroaryl or heterocycloalkyl optionally substituted with 1 to 3 groups selected from alkyl groups, -SO 2 -alkyl and -COOR 5. Preparation process and therapeutic application |