| abstract |
The invention relates to novel products of formula (I): ## EQU1 ## where Het represents an aromatic heterocycle or partially unsaturated, mono or bicyclic, containing from 1 to 4 N, O or S heteroatoms, optionally substituted with the same or different R1 or R'1; R is X- (AB) n-CONH2, X- (AB) n0-CONH2, X- (AB) n-NH-CONH2, X- (CH2) m -heterocycloalkyl, X- (CH2) m-aryl and X - (CH 2) m -heteroaryl with X is -OC (O), -NH-C (O), NH-CS, -NH-CO-CH 2 -O-; -NH-CO-CH 2 -S-CH 2 -CO-NH-; -NH-CO- (CH 2) 2 -SO 2 -; -NH-CO-CH 2 -N (CH 3) -CO-; A and B, which are identical or different, independently represent a single bond, CH 2, CH-alkyl, CH-aralkyl, n = 1.2 and m = 0.1; R1 and / or R'1 represent H, halogen, CF3, nitro, cyano, alkyl, hydroxy, mercapto, amino, alkylamino, dialkylamino, alkoxy, alkylthio, carboxy free or esterified with an alkyl radical, carboxamide, CO-NH (alkyl ), CON (alkyl) 2, NH-CO-alkyl, sulfonamide, NH-SO 2 -alkyl, S (O) 2 -NHalkyl, S (O 2) -N (alkyl) 2, all of these alkyl, alkoxy and alkylthio radicals being themselves possibly substituted; these products being in all isomeric forms and salts as medicaments. |