| abstract |
The invention relates to compounds of formula (I): wherein A represents a bond, an oxygen atom or a -O-CH2- group; Ar1 represents a phenyl or heteroaryl group; Ar 2 represents a phenyl group, a heteroaryl group or a heterocycloalkyl group; R1a, b, c and R2a, b, c each represent a hydrogen or halogen atom or an alkyl group, -OR5, hydroxy-alkyl, alkoxy-alkyl, alkoxy-alkoxy, haloalkyl, -O-haloalkyl , oxo, -CO-alkyl, -CO-haloalkyl, -COOR5, alkyl-COOR5, -O-alkyl-COOR5, -SO2-alkyl, -SO2-haloalkyl, alkyl-SO2-alkyl, -SO2NR6R7, -CONR6R7, - alkyl-CONR6R7 or -O-alkyl-NR6R7; R3 represents a hydrogen atom or an alkyl; R4 represents a hydrogen or halogen atom or a cyano group, -OR5, hydroxyalkyl, -COOR5, -NR6R7, -CONR6R7, -SO2-alkyl or -SO2-NR6R7; R8 represents a hydrogen atom or a group of formula -B-Het, where B may be absent or represent a bond, an oxygen atom or a group -CO- or -SO2- and where Het represents an optionally substituted heterocycloalkyl by 1 to 3 groups selected from alkyl groups, -SO 2 -alkyl and -COOR 5. Preparation process and therapeutic application |