| abstract |
Kinase inhibitors of formula (I) with R1 to R4 = H; ether, polyether, amino; NO2; NH-carbamate; NH-CO-R, with R = C1-C12 alkyl; N3 and its 1,2,3-triazole derivatives; R5 = -OH; halogen; -OR with R as defined above; OH-carbamate; OH-carbonate ketone; NH2, NH-carbamate; NH-CO-R, with R as defined above; N3 and its 1,2,3-triazole derivatives; N (R9, R10); R5 '= H or C1-C12 alkyl; R6 = H; R; (R or R ') 3-Si, R being as defined above; optionally substituted aryl, heteroaryl; halogen (iodine); alkynyl; - R7 and R8 = H, C1-C12 alkyl; - R9 and R10, = H, R (or R ') as above.Application as kinase inhibitors, in particular for the treatment of cancers. |