http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2923485-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ffb85f8dcab129d793000ada40009bb4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-04 |
| filingDate | 2007-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c128a88c74f1e1096555f833836cbab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_effb42308a1185617f5d8d17df8c2652 |
| publicationDate | 2009-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | FR-2923485-A1 |
| titleOfInvention | ANTIMITOTIC COMPOUNDS DERIVED FROM VINCA ALKALOIDS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| abstract | The compounds of the invention are new derivatives of the vinblastine and vinflunine family modified at positions -4, -4 ', -20', and substituted at position -12 '. These new derivatives correspond to the general formula next: in which:. R1 represents the following groups: - -C = CR <1> in which R 'represents a hydrogen atom, an alkyl group of one to six linear or branched carbon atoms, a -CH2-O-alkyl group, a group trialkylsilyl, an amino group -CH2-NXY in which X and Y independently represent a hydrogen atom or an alkyl, aryl or heteroaryl group, or can together form a 5 to 7 membered ring, - SR "in which R" represents a hydrogen atom, a linear or branched one to six-membered hydroxy-alkyl, hydroxy-alkenyl or hydroxy-alkynyl group, an optionally substituted benzyl or aryl group, in which R "'represents an OCO-Z ester function, where Z is an alkyl, alkenyl, linear or branched alkynyl group, an optionally substituted aryl or benzyl group, R2 and R3 together or independently represent a hydrogen atom or a halogen atom. R4 represents a hydrogen atom or an acetyl group .. n can take the values 1 or 2. The invention also relates to the application of these compounds or their salified forms to the treatment of cancerous pathology. |
| priorityDate | 2007-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 99.