| abstract |
The invention relates to tricyclic N-heteroarylcarboxamide derivatives of general formula (I) in which: A represents, with the Z2-Z3 bond of the bicycle to which it is fused, a C4-C7-cycloalkyl group, a monocyclic heterocycle or a monocyclic 4- to 7-membered heteroaryl comprising from one to three heteroatoms selected from O, S or N, including Z2 and Z3; Z1, Z5, Z6, Z7 and Z8 represent, independently of one another, a nitrogen atom, a carbon atom or a C-R2 group; Z2, Z3, Z4 and Z9 represent, independently of one another, a nitrogen atom or a carbon atom and Z1, Z2, Z3, Z4, Z5, Z6, Z7, Z8 and Z9 together form a bicyclic heteroaryl bonded to the nitrogen atom of the amide or thioamide of formula (I) at positions Z5, Z6, Z7 or Z8 when these positions correspond to a carbon atom, at least one of Z4, Z5, Z6, Z7, Z8 and Z9corresponding to a nitrogen atom; W represents an oxygen or sulfur atom; P is indolyl, pyrrolo [2,3-c] pyridinyl, pyrrolo [2,3-b] pyridinyl, pyrrolo [3,2-b] pyridinyl or pyrrolo [3,2-c] pyridinyl.A process for the preparation and therapeutic application. |