| abstract |
The invention relates to the novel products of formula (I): in which Het represents a mono or bicyclic heterocycle, from 1 to 4 heteroatoms selected from N, O or S, optionally substituted, R 1 represents X- (AB) n-CONH 2, X- (AB) nO-CONH2, X- (AB) n-NH-CONH2, X- (CH2) m -heterocycloalkyl, X- (CH2) m -aryl and X- (CH2) m -heteroaryl with X represents - OC (O), -NH-C (O), NH-CS, -NH-CO-CH 2 -O-; -NH-CO-CH 2 -S-CH 2 -CO-NH-; -NH-CO- (CH 2) 2 -SO 2 -; -NH-CO-CH 2 -N (CH 3) -CO-; A and B are single bond, CH2, CH-alkyl, CH-aralkyl, n = 1.2 and m = 0.1; R2 and R'2 represents H, halogen, CF3, nitro, cyano, alkyl, hydroxy, mercapto, amino, alkylamino, dialkylamino, alkoxy, alkylthio, carboxy free or esterified with an alkyl radical, carboxamide, CO-NH (alkyl) and NH-CO-alkyl; p = 1 to 4 and p '= 1 to 3; L represents a single bond, CH 2, C (O), O, S or NH, all of these radicals being optionally substituted, these products being in all isomeric forms and salts, as medicaments. |