| abstract |
The invention relates to the application of zwitterionic hemispherical surfactants of the amidosulfobetaine type to two-dimensional gel electrophoresis on high resolution gel, one of the most efficient separative methods of proteomic analysis; the compounds concerned by this application have the following general formula: where 1 = 2, 4, 6, 8 or 10, m is an integer from 2 to 12, n and p are integers greater than or equal to 1 These compounds are useful as agents for extracting and solubilizing tissue, cell and membrane proteins, followed by two-dimensional electrophoresis. |