http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2891829-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fbe7b9e0223f5f7d55457f219b9c718d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 |
| filingDate | 2005-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16610b1f2605875015425a7dcae59f02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_601feaa26f2d10f8dac2b5a183112900 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84cd6e7f125fb9ffd835dcae40f6e8b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f35e36d48f86cb730de435a0118f8499 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eae1aa70c24ccdc11a8936726f315c48 |
| publicationDate | 2007-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | FR-2891829-A1 |
| titleOfInvention | 4-AMINO-QUINAZOLINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF |
| abstract | The invention relates to 4-amino-quinazoline derivatives of general formula (I) wherein: A, B = C1-4-alkylene optionally substituted; L = single bond, C1-2-alkylene, -CH = CH- or -C = C-; the C1-2-alkylene groups and -CH = CH- being optionally substituted, or L = cycloprop-1,2-diyl; R = H, C1-5-alkyl, C1-3-fluoroalkyl, C3-6-cycloalkyl, -C (O) C1-3-alkyl, C1-3-alkylene-C3-6-cycloalkyl, -CH2-C = CH, C2-4-alkylene-NRaRb, C1-3-alkylene-X-C1-3-alkyl wherein X = O, SO2; R1 = aryl or heteroaryl; optionally substituted; R2 and R3 = H, C1-3-alkyl or C1-3-fluoroalkyl, or R2 and R3 together form cycloprop-1,1-diyl; R4 = H, C1-5-alkyl, C1-3-fluoroalkyl, C1-5-alkoxy, -SF5, C1-3-alkylene-X-C1-3-alkyl where X = O or SO2, C1-5-alkylene -NRaRb, an optionally substituted aryl or heteroaryl; R5 = H, halogen, C1-5-alkyl, C1-3-fluoroalkyl, C1-5-alkoxy, C3-6-cycloalkyl, C1-3-alkylene-C3-6-cycloalkyl, C1-3-alkylene-O- C1-3-alkyl, C1-3-alkylene- (OH), C1-3-alkylene-X-C1-3-alkyl wherein X = S, SO or SO2, or R5 = -NRaRb, C1-3-alkylene -NRaRb, aryl, C1-3-alkylene-aryl, -O-aryl, C1-3-alkylene-O-aryl, C1-3-alkylene-O-C1-3-alkylene-aryl, heteroaryl or C1-3- optionally substituted alkylene-heteroaryl, or R5 = heterocycle optionally substituted with C1-3-alkyl, -C (O) C1-3-alkyl, -C (O) C1-3-fluoroalkyl, C1-3-alkylene-C3-6 -cycloalkyl, optionally substituted C1-3-alkylene-aryl, C1-3-alkylene-heteroaryl; R7 = H, halogen, C1-5-alkyl, C1-3-fluoroalkyl, C1-5-alkoxy, -COOH, -C (O) O-C1-3-alkyl, C1-3-fluoroalkoxy, C1-3- alkylene- (OH), -NO2, -CN, -X-C1-3-alkyl wherein X is S, SO or SO2, or R7 = -NRaRb, C1-3-alkylene-NRaRb, -C (O) - NRaRb, -C (O) -C 1-3 -alkyl, aryl, -O-aryl or optionally substituted heteroaryl; in the form of a base or an acid addition salt, as well as a hydrate or solvate state.Procedure for preparation and application in therapy. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8193203-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009143058-A1 |
| priorityDate | 2005-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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