| abstract |
The invention relates to compounds of general formula (I): wherein n is 1, 2 or 3; the pyrrolopyridine ring is 4-, 5-, 6- or 7-pyrrolopyridine optionally substituted in carbon position 4, 5, 6 and / or 7 by one or more substituents X, which are identical or different from one another; Z1, Z2, Z3, Z4 and Z5 represent, independently of one another, a hydrogen or halogen atom or a C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl- C1-C3-alkylene, C1-C6-fluoroalkyl, C1-C6-alkoxy, C1-C6-fluoroalkoxy, cyano, C (O) NR1R2, nitro, NR1R2, C1-C6-thioalkyl, -S (O) -C1- C6-alkyl, -S (O) 2-C1-C6-alkyl, SO2NR1R2, NR3COR4, NR3SO2R5, aryl-C1-C6-alkylene or aryl, aryl and aryl-C1-C6-alkylene being optionally substituted; W represents a fused bicyclic group of formula: attached to the nitrogen atom at the 1, 2, 3 or 4 positions; A represents an optionally substituted 5- to 7-membered heterocycle comprising from one to three heteroatoms selected from O, S or N; in the form of a base or an acid addition salt, as well as a hydrate or solvate state.Procedure for preparation and application in therapy. |