| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2bed2d03a961e918f0969752acc4006d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4e1dfcbdcafbe3a4a72ef04553310205 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-142
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-49 |
| filingDate |
2005-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2010-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fdf9bf46ea39f66d610b510e72bc5087
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81744a5c8bb9574569751ed2aeb5b26b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad30d16632b6dc2cbad1746a0fed24e0 |
| publicationDate |
2010-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
FR-2884257-B1 |
| titleOfInvention |
PREVENTION OF TOXICITIES DUE TO 5-FLUOROURACILE |
| abstract |
Method for the in vitro diagnosis of increased sensitivity to 5-fluorouracil, said method comprising carrying out on one or more biological samples, including at least one blood sample, the combination of at least two in vitro tests chosen from the group consisting measuring the plasma uracil concentration, measuring the ratio of plasma dihydrouracil / uracil concentrations, and determining the presence or absence of a mutation in the gene encoding dihydropyrimidine dehydrogenase. It also relates to a method of in vitro diagnosis of the predisposition of a subject to the development of toxicity following a treatment comprising 5-fluorouracil, as well as a method of in vitro evaluation of the dose of 5. -fluorouracil suitable for a patient with a disease which can be treated with 5-fluorouracil. |
| priorityDate |
2005-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |