| abstract |
The invention also provides a product comprising (1R) -1 - [({(2R) -2-amino-3 - [(8S) -8- (cyclohexylmethyl) -2-phenyl-5,6-dihydroimidazo [ 1,2-a] pyrazin-7 (8H) -yl] -3-oxopropyl} dithio) methyl] -2 - [(8S) -8- (cyclohexylmethyl) -2-phenyl-5,6-dihydroimidazo [1, 2-alpha] pyrazin-7 (8H) -yl] -2-oxoethylamine in combination with an analgesic agent selected from morphine, an analogue or derivative of morphine, sodium channel inhibitors, nonsteroidal anti-inflammatory drugs (NSAIDs) ), glutamatergic system inhibitors, tricyclic antidepressants, and gabaergic derivatives for simultaneous, separate, or temporal therapeutic use in the treatment or prevention of pain. |