| abstract |
Cosmetic, pharmaceutical and dermopharmaceutical compositions for preventing and / or combating wrinkles and fine lines in the skin caused and / or accentuated by the contractions of the subcutaneous muscles. Among the causes of the formation of wrinkles there is intrinsic genetic aging, accentuated by exogenous causes such as free radicals, all of which lead to a stiffening of the skin fibers and a loss of flexibility. The very numerous movements of the skin under the influence of the movements of the subcutaneous muscles, make the more or less rigidified fibers form fine lines then wrinkles which will tend to become permanent. Besides the numerous preparations intended to fight against the causes of aging and the establishment of wrinkles, the reduction of contractions of the subcutaneous muscles appears as a particularly interesting way. Botulinum toxin works well in this approach. It must be injected subcutaneously, but its use is very delicate and reserved to the dermatologists savvy. The need has therefore been felt to seek molecules or extracts having a topical action and a greater safety of The present invention describes the family of stilbenes which exhibits this surprising property of reduction of muscular contractions, hitherto undescribed for this chemical family. A nerve-muscle co-culture test is described. which makes it possible to verify this property of inhibition of muscle movements, in particular for Resveratrol and its oligomers, analogs, glucosides and acetates. The invention describes compositions for application to the skin and intended to prevent and / or fight against the formation of wrinkles and fine lines of the skin by limiting the contractions of the subcutaneous muscles, and characterized by what they contain of Resv ratrol, and / or one or more oligomers and / or the like, and / or their glycosides, and / or acetates, and / or one or more plant extracts containing one or more of these elements. |