http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2865934-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0264ab149dd139d522f7f14b1a3ea9e2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4353 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 |
| filingDate | 2004-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2006-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7ab9420e4daab6e10acc04547924c7d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9733f273e08d5e89d88ef279dda9342a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d72fdadc55c4ac0a017e43680c87801 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d55ab3fc1b3eb4f533d08438fae5ac3f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9d9ff4e988e2f223cedb6c483336ecb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b999a735fc37a5117ba7eeb57c843848 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54e250df98e3998975e30213eea607da |
| publicationDate | 2006-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | FR-2865934-B1 |
| titleOfInvention | USE OF SUBSTITUTED 1,2,3-INDOLIZIN DERIVATIVES, FGFS INHIBITORS, FOR THE PREPARATION OF MEDICAMENTS USEFUL FOR THE TREATMENT OF DISEASES ASSOCIATED WITH CHOROIDAL PATHOLOGICAL ANGIOGENESIS |
| abstract | Use of 1, 2, 3 substituted indolizine derivatives (I) or their salts in the preparation of medicaments for the treatment of diseases related to the pathological choroid angiogenesis. - Use of 1, 2, 3 substituted indolizine derivatives of formula (I) or their salts in the preparation of medicament for the treatment of diseases related to the pathological choroid angiogenesis - R1 = OH, 1-5C alkoxy, carboxy, 2-6C alcoxycarbonyl, -NR5R6, -NH-SO2-Alk, -NH-SO2-Ph, -NH-CO-Ph, -N(Alk)-CO-Ph, -NH-CO-NH-Ph, -NH-CO-Alk, -NH-CO2-Alk, -O-(CH2)n-cAlk, -O-Alk-COOR7, -O-Alk-O-R8, -O-Alk-OH, -O-Alk-C(NH2):NOH, -O-Alk-NR5R6, -O-Alk-CN, -O-(CH2)n-Ph, -O-Alk-CO-NR5R6, -CO-NH-(CH2)m-COOR7 or -CO-NH-Alk; - Alk = 1-5C alkyl or 1-5C alkylene; - cAlk = 3-6C cycloalkyl; - R5, R6 = H, 1-5C alkyl or benzyl; - R7 = H or 1-5C alkyl; - R8 = 1-5C alkyl or -CO-Alk; - Ph = phenyl (optionally substituted by one or more of halo, 1-5C alkoxy, carboxy or 2-6C alkoxycarbonyl); - R2 = H, 1-5C alkyl, 1-5C haloalkyl comprising 3-5 halogen atoms, 3-6C cycloalkyl or phenyl optionally substituted by one or more halo, 1-5C alkoxy, carboxy or 2-6C alkoxycarbonyl; - A = -CO-, -SO- or -SO2-; - R9, R10 = H or 1-5C alkyl; - R11 = H or -Alk-COOR12; - R12 = H, 1-5C alkyl or benzyl; - HetN = heterocycle having 5 or 6 chains comprising at least one atom of N and optionally another heteroatom of N or O; either - R3, R4 = H, 1-5C alkoxy, NH2, carboxy, 2-6C alkoxycarbonyl, OH, NO2, hydroxyamino, -Alk-COOR7, -NR5R6, -NH-Alk-COOR7, -NH-COO-Alk, -N(R11)-SO2-Alk-NR9R10, -N(R11)-SO2-Alk, -N(R11)-Alk-NR5R6, -N(R11)-CO-Alk-NR9R10, -N(R11)-CO-Alk, -N(R11)-CO-CF3, -NH-Alk-HetN, -O-Alk-NR9R10, -O-Alk-CO-NR5R6 or -O-Alk-HetN; or - R3+R4 = an unsaturated heterocycle having 5-6 chains (when R3 is alkoxy, R4 is -O-Alk-NR9R10 or OH, and R1 does not represent an alkoxy); - m = 1-5; and - n = 0-5. - ACTIVITY - Antiangiogenic; Ophthalmological; Antiinflammatory; Vasotropic. - MECHANISM OF ACTION - Fibroblast growth factor inhibitor. |
| priorityDate | 2004-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.