abstract |
A compound of general formula (I): wherein m is 0, 1, 2 or 3; n represents 0, 1, 2 or 3; X represents an oxygen or sulfur atom or an SO or SO2 group; R1 and R2 are, independently of one another, a hydrogen atom or a C1-3-alkyl group, or R1 and R2 together form a - (CH2) p- group, where p represents an integer ranging from from 1 to 5 such that n + p is an integer from 2 to 5; R3 represents a hydrogen or fluorine atom or a hydroxyl or methyl group; R4 represents a group of the general formula CHR5CONHR6 in which R5 represents a hydrogen atom or a C1-6-alkyl group and R6 represents a hydrogen atom or a C1-6-alkyl, C3-7-cycloalkyl, C3- 7-cycloalkyl-C 1-6 -alkylene; Y represents a group chosen in particular from phenyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, naphthyl, quinolinyl, isoquinolinyl, phthalazinyl, quinazolinyl, quinoxalinyl, naphthyridinyl, cinnolinyl, benzofuranyl, dihydrobenzofuranyl, benzothienyl, dihydrobenzothienyl, indolyl, isoindolyl, indolinyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzoxadiazolyl, benzothiadiazolyl, this group being optionally substituted; in the form of a base, an acid addition salt, a hydrate or a solvate.Application in therapeutics. |