| abstract |
The present invention relates to low-dose tablets obtained by direct compression of microgranules which essentially consist of a neutral support, covered with a polymer layer comprising at least one pharmaceutically acceptable polymer and allowing the modified release of active principles in an aqueous medium. , to which is applied an active layer comprising at least one active principle. The tablets according to the invention advantageously have a matrix effect similar to that obtained with conventional matrix tablets, which depends on the nature of the polymer or polymers used for the constitution of the polymer layer. This matrix effect allows modulation of the release profile of the active ingredient transported as a function of the type of polymer used. Such tablets are particularly suitable for the production of low-dose tablets. The present invention also relates to the process for the manufacture of these tablets, as well as to their use, in particular for the administration of low to very low-dose active principles. |