| abstract |
A medicament comprising, in a pharmaceutically acceptable vehicle, an anti-psychotic or an antidepressant (A), exhibiting only an adverse effect of body weight gain or sedation and an antagonist and / or inverse agonist (B) of the H3 receptor of the histamine, said histamine H3 receptor antagonist and / or inverse agonist being present in a therapeutically effective amount to achieve at least one of the following three effects: suppressing or at least limiting the undesirable effect of weight gain, suppression or limitation of the undesirable effect on the vigilance, increase of the pro-cognitive effect of the treatment. Use of such an antagonist or inverse agonist for the preparation of a medicament for providing at least one of said three effects in a patient treated with such an antipsychotic or antidepressant. |