abstract |
The invention relates to a double-stranded oligonucleotide characterized in that it consists of two oligonucleotide sequences of the same size each comprising at the same end 3 'or 5' one to five unpaired nucleotides forming single-stranded ends brimming with hybrid, one of said oligonucleotide sequences being substantially complementary to a target sequence belonging to a DNA or messenger RNA molecule of a gene that is to be specifically repressed. |