| abstract |
Pharmaceutical composition for oral use comprising, as active principle, an active principle capable of undergoing a powerful effect of first intestinal passage, characterized in that it is in the form of a self-micro-emulsifiable system in contact with an aqueous phase, comprising: - a therapeutically effective amount of said active principle; - a lipophilic phase comprising a mixture of glycerol mono, di, and triesters and of PEG mono and diesters with at least one fatty acid chosen from the group comprising: C8 -C18 fatty acids; - A surfactant phase comprising a mixture of mono, di and triesters of glycerol and of mono and diesters of PEG with caprylic (C8) and capric (C18) acids; - A cotensioactive phase comprising at least one polyvalent alcohol ester with at least one fatty acid chosen from the group comprising the caprylic esters of propylene glycol, the lauric esters of propylene glycol and the oleic esters of polyglycerol. - the TA / CoTA ratio being between 0, 2 and 6. |