| abstract |
The present invention relates to a compound of formula (I): (CF DRAWING IN BOPI) in which R5 is chosen from the groups 3-pyridinyl, 5-pyrimidinyl, -CONH-alkyl in C1-C4, -NHCO-alkyl in C1- C4, halogen, -CO2 R where R can be hydrogen or C1-C4 alkyl, -SO2 NH2 , -NO2 , -CF3 , (CF DRAWING IN BOPI) in which Ar is chosen from 5-imidazolyl, 2-pyrrolyl groups optionally substituted by a C1-C4 alkyl, 2-furyl, or 2-thiazolyl radical, in the E, Z form or a mixture of the two forms of isomers. This invention is applicable as a medicament making it possible to block the division of proliferating cells during the cycle and inducing cell apoptosis for the treatment of primary tumors and secondary cancers. |