abstract |
Biotin derivatives of the following general formula (I): (CF DRAWING IN BOPI) in which - R1 represents a specific compound, - X1 represents a carbon chain, preferably from 1 to 10 carbon atoms, substituted or not, comprising the optionally one or more carbonyl or oxycarbonyl groups, and / or an -NH- group, in particular a chain of formula -HN (CH2) n -O-CO- in which n is an integer from 1 to 5 and comprising the case optionally one or more ether, amide and / or amine functions - Y represents a hydrocarbon chain of 1 to 5 carbon atoms, substituted or not, - R2 represents a hydrogen atom, or a protective group, in particular R2 represents a alkyl group of 1 to 5 carbon atoms. Application: use as vectors, in particular in the context of the implementation of methods for detecting interactions between biological compounds, as well as in pharmaceutical compositions. |