| abstract |
The invention relates to benzimidazole derivatives, of general formula (CF DRAWING IN BOPI) in which X represents a nitrogen atom or a carbon atom; and in the case where X represents a nitrogen atom, R3 represents in particular a hydrogen atom or a (C1-C4) alkyl group, R4 represents in particular a hydrogen atom; a (C1-C6) alkyl group; (C3-C7) cycloalkyl; 4-piperidyl; - (CH2) p -NR5R6; - (CH2) p -CONR5R6; - (CH2) p -phenyl; - (CH2) p -morpholinyl; - (CH2) p -pyrrolidinyl; - (CH2) p -tetrahydroisoquinoline; - (CH2) p -heteroaryl; heteroarylcarbonyl; phenylcarbonyl; (C1-C6) alkylcarbonyl; - (CH2) p -COOR '; or else a phenylsulfonyl group; and in the case where X represents a carbon atom R3 represents a hydrogen atom; a group -NR5R6; -NHCOR7; -CONHR5; -COR7; -NHCONH2; -OH or -CH2 OH, R4 represents in particular a hydrogen atom; an optionally substituted phenyl group; a heteroaryl group; or else a group - (CH2) t NR7R8. Method of preparation and application in therapy. |