| abstract |
The invention relates to compounds of formula (I) (CF DRAWING IN BOPI) in whichR1 and R2 independently represent a hydrogen atom, a benzoyl group, a -CO (C1 -C4) Alk group, a -CH2 OCH3 group, a -COO (C1 -C4) Alk group or a benzyloxycarbonyl group; or R1 and R2 together form a carbonyl, methylene or di (C1 -C4) Alk-methylene group to constitute a heterocyclic structure with the oxygen and nitrogen atoms which carry them; R3 represents a hydrogen atom or a group (C1 -C4) Alk, R4 represents a (C1 -C4) alkoxy group, or a -NR5 group R6, R5 and R6 independently represent a hydrogen atom, a (C1 -C4) Alk group, an aryl or heteroaryl group , optionally substituted by a group R7; an aralkyl or heteroaralkyl group, optionally substituted by a group R7; or else R5 and R6, with the nitrogen atom which carries them, represent a ring of 5 to 7 atoms, saturated or unsaturated; R7 represents a hydrogen or halogen atom, a hydroxy group, a group (C1 -C4) Alk, a (C1 -C4) alkoxy group, - COOH, -CN, -NH (C1 -C4) Alk or -N (C1 -C4) 2 Alk; X represents an oxygen atom or a methylene group and their salts or solvates, the pharmaceutical compositions containing them, a process for their preparation, and synthetic intermediates. |