| abstract |
The invention relates to a formulation in the form of a solid dispersion containing Itraconazole and a hydrophilic polymeric excipient, characterized in that it has a percentage of dissolution in vitro greater than 40%, preferably greater than 60%, after 2 hours, measured in a continuous flow cell at pH 1, 2 D, at a flow rate of 16 ml / mm. This formulation contains sorbitol combined with a copolymer of ethylene oxide and propylene oxide or a mixture of copolymer of ethylene oxide and of copolymer of propylene oxide. |