| abstract |
The subject of the present invention is compounds of general formula I: (CF DRAWING IN BOPI) in which: - R1 represents an alkyl, alkenyl or alkynyl, cycloalkyl, or (cycloalkyl)alkyl chain substituted by at least one group -COOH, SO3 H, PO3 H2 , or tetrazolyl.- R4 represents an alkyl, aryl, arylalkyl, cycloalkyl, (cycloalkyl) alkyl, (heteroaryl) alkyl, heterocycloalkyl or (heterocycloalkyl) alkyl chain substituted by at least one CO2 H, CONH2 , SO3 H group , SO2 NH2 , PO3 H2 or tetrazolyl.It also relates to the use of said compounds as selective inhibitors of aminopeptidase A. |