| abstract |
The invention relates to novel histidine derivatives corresponding to the following general formula (I): (CF DRAWING IN BOPI) in which: n is an integer ranging from 0 to 5, n 'is an integer ranging from 1 to 16 R represents a side chain of an amino acid, X represents a radical chosen from the radicals of formulas, read from left to right: -NH-CO-, -SO2-, -NH-CO-CO-, -O-CO- CO-, R 'represents a linear or branched, saturated or unsaturated, optionally hydroxylated, C6 to C22 alkyl radical or a C6 to C22 aminoalkyl radical, the amine function being optionally protected in the form of acetamide or substituted by one or two lower alkyl groups, Q + represents H + or an organic or inorganic cation, as well as the addition salts of a compound of formula (I) with an organic or inorganic acid. The invention relates both to the compounds with D configuration and L configuration as well as their mixtures, in particular the racemic mixture of the compounds D and L. The invention also relates to a process for the preparation of the compounds of formula (I) as well as the use of these compounds in cosmetics and in pharmacy. |