| abstract |
The invention provides methods and constructs for the production of retroviral particles, in vitro, ex vivo, or in vivo. It also relates to the use of these methods and constructs for the transfer of nucleic acids into cells. The invention relates more particularly to a composition comprising all the genetic elements necessary for the constitution of a retroviral particle, incorporated into one or more recombinant adenoviruses defective for all or part of the E1 and E4 regions at least (chimeric adeno-retro vectors ). |