| abstract |
The invention relates to the field of devices implantable in the body. The device comprises an electroconductive support covered with a layer of electroconductive polymer derived from pyrrole, naphthalene or thiophene, on which is encapsulated at least one biologically active substance of anionic nature, and in particular an antisense oligonucleotide. support is carried out, in a first step, by electropolymerization directly on the metal support, or, according to a variant, by depositing the polymer in solution on the metal support, then, in a second step, by electrochemical oxidation and fixation of the substance biologically active of anionic nature on the polymer. Application in cardiology to the preparation of stents for the treatment of restenosis. |