| abstract |
The present invention relates to a fiber of an adenovirus modified by mutation of one or more residues, said residues being directed towards the natural cellular receptor of said adenovirus at the level of the three-dimensional structure. It also relates to a DNA fragment, an expression vector and a cell line expressing said fiber. Finally, it relates to an adenovirus comprising it, the process for producing such an adenovirus and an infectable host cell as well as their therapeutic use and a corresponding pharmaceutical composition. |