| abstract |
The invention relates to quinoline derivatives corresponding to formula I (CF DRAWING IN BOPI) in which Ra, Rb and Rc, identical or different from each other, represent one or more substituents, themselves identical or different, occupying any position on the rings, this or these substituents being chosen from, a group - (CH2) 8 -Y or -CH = CH-Y, where Y represents a halogen atom, a radical -OH, -OR, - COH, -COR, -COOH, -COOR, -COH, -COR, -CONH2, -CON (Rx, Ry) -CH = NOH, -CO-CH = NOH, -NH2, -N (Rx, Ry), -NO2, -PO (OR) 2, -SH2, -SR, -SO2 R, -SO2 NHR, CN, or Z (Rc), where R represents an alkyl radical of 1 to 8 carbon atoms, or an aryl radical or heterocyclic, Rx and Ry, which are identical or different represent an alkyl radical of 1 to 5 carbon atoms, Z represents an aryl or heterocyclic radical and n is zero or an integer from 1 to 5, Rb possibly also representing an atom of hydrogen, and when Y represents a -COOH or -COOR group in Rc, Z, if represents an aryl group, has at least 3 substituents or the quinoline ring is trisubstituted, - X represents an ethylenic double bond, a group - (CH2) n -, where n is an integer from 1 to 5, or a group -CH ( Rd) -CH (Re), Rd and Re. identical or Rb possibly also representing a hydrogen atom, different representing a hydrogen or halogen atom, a hydroxy or epoxy group, as well as the pharmaceutically acceptable salts of these derivatives, their diastereomeric forms and their enantiomeric forms. Application as a medicament with an anti-integrase inhibitory effect of HIV. |