| abstract |
The subject of the invention is the products of formula (I): (CF DRAWING IN BOPI) in which A represents a carboxy, cyano, nitrogenous heterocycle, nitro, HONHCO-, Ba represents a single bond, (CH2) n, n = 1 to 6, (CH2) n-1 -CH (Alk1), Alk1 being a C1-8 alkyl, or O- (CH2) n ', n' = 1 to 6, Ra and Rb represent hydrogen, alkyl C1- 8, C1-12 acyl, phenyl, benzyl, diphenymethyl, trityl or together with the nitrogen atom to which they are attached form a saturated or unsaturated nitrogenous heterocycle optionally substituted, R1, R2, R3 and R6 represent hydrogen, halogen, alkyl 1-8 optionally substituted, 1-8 alkoxy, 1-8 alkylthio, nitro, cyano, -CF3, amino, C1-8 alkylamino, C2-16 dialkylamino, -NR'a R'b in which R'a and R ' b together with the nitrogen atom to which they are attached form an optionally substituted saturated or unsaturated nitrogen heterocycle containing 1 to 4 atoms, R4 and R5 represent the same values as R1, R2, R3, or R6, or together form a -CH group = CH-CH = CH- as well as the addition salts thereof, their preparation process and the intermediates of this process, their application as medicament and the pharmaceutical compositions containing them. |