http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2730492-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37555e87c88017b74fba94c8b8abbb42 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-1005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-1013 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-103 |
| filingDate | 1995-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1af3a50261c602bdd49db15c37f27452 |
| publicationDate | 1996-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | FR-2730492-A1 |
| titleOfInvention | NOVEL FARNESYL TRANSFERASE INHIBITORS, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| abstract | New farnesyl transferase inhibitors of general formula (I), their preparation and the pharmaceutical compositions which contain them. (CF DRAWING IN BOPI) In general formula (I), R1 represents YS-A1 - (Y = hydrogen atom, amino acid residue, fatty acid residue, alkyl or alkoxycarbonyl radical, or R4 -S- radical in which R4 represents an alkyl radical containing 1 to 6 carbon atoms optionally substituted by a phenyl radical, or radical of general formula (CF DRAWING IN BOPI) in which A1, X1, Y1, R2, R'2, X2, Y2, X, R3, R'3 and R are defined as below, and A1 = alkylene radical containing 1 to 4 carbon atoms optionally substituted in alpha of the group> C (X1) (Y1) by an amino, alkylamino or alkanoylamino radical , alkoxycarbonylamino), X1 and Y1 each represent a hydrogen atom or together with the carbon atom to which they are attached form a group> C = O, R2 represents a straight or branched alkyl radical containing 1 to 4 carbon atoms optionally substituted by a cyclohexyl radical, R'2 represents hydrogen or alkyl, X2 and Y2 each represent an at hydrogen atom or together with the carbon atom to which they are attached form a group> C = O, R3 represents an alkyl radical containing 1 to 4 carbon atoms optionally substituted by hydroxy, alkoxy, mercapto, alkylthio, alkylsufinyl or alkylsulfonyl , it being understood that, when R3 represents an alkyl radical substituted by a hydroxy radical, R3 can form, with the alpha carboxy radical, a lactone, R'3 represents hydrogen or alkyl, X represents an oxygen or sulfur atom, and R represents a hydrogen atom or an optionally substituted alkyl radical or an optionally substituted phenyl radical. . These new products exhibit anticancer properties. |
| priorityDate | 1995-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 130.