| abstract |
The subject of the present invention is chemical compounds consisting of an oligo-4'-thio-2 'deoxyribonucleotide or an oligo-4'-thioribonucleotide alpha or beta, characterized in that they comprise a chain of 4'-thio-2 'deoxyribonucleotides or 4'-thioribonucleotides respectively, chain possibly optionally linked to an effector agent, in particular a radical corresponding to an intercalating agent or a chemical or photoactivatable radical, such as a radical carrying a function which reacts directly or indirectly with chains of nucleotides or a radical whose presence allows easy and sensitive detection. The present invention also relates to mixed oligomers comprising oligothionucleotides linked to DNA or RNA type sequences. It also relates to methods of preparing these compounds and their therapeutic, diagnostic applications or as laboratory reagents. |