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classificationCPCAdditional http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55
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filingDate 1992-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7664d248bac079ee0424985f8171377
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publicationDate 1993-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber FR-2687150-A1
titleOfInvention PROCESS FOR THE PREPARATION OF TAXANE DERIVATIVES
abstract Process for the preparation of taxane derivatives of general formula (I) by esterification at a temperature between -10 and 60 ° C of a baccatin III derivative or of 10-deacetyl baccatin III of general formula (II) by means of an acid of general formula (III) followed by the replacement of the protective groups G1, G2 and R2 of the product obtained by hydrogen atoms. In formulas (I), (II) or (III): - Ar represents an aryl radical - R represents hydrogen or acetyl - R1 represents benzoyl or tert.butoxycarbonyl - G1 represents a protective group of the hydroxy function, G2 represents the radical acetyl or a protective group for the hydroxy function and R2 represents a protective group for the hydroxy function.
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