| abstract |
The subject of the invention is compounds of formula: (CF DRAWING IN BOPI) in which: - Y represents an Ar- (CH2) x -CX group in which. Ar represents phenyl; pyridyl, thienyl; . x is zero or one; . X represents an NH-CO-Alkyl group; . m is 2 or 3; - Ar 'represents a phenyl; thienyl, benzothienyl; naphthyl or indolyl; - R represents hydrogen, a C1 -C6 alkyl; - T represents -CO- or -CW-NH-, W being an oxygen or sulfur atom, and - Z represents either hydrogen, or M or OM when T represents the group -CO-, or M when T represents the group -CW-NH-; M represents an alkyl; a phenylalkyl; a pyridyalkyl; a naphthylalkyl; a pyridylthioalkyl: a styryl; an optionally substituted mono-, di- or tricyclic aromatic or heteroaromatic group; or one of its salts with mineral or organic acids. Application: Medicines, in particular for the treatment of pathological phenomena involving the neurokinin systems. |