| abstract |
New thiopyranopyrrole derivatives of general formula (I) in which X is an oxygen atom or an NH radical, R1 is optionally substituted phenyl, cyclohexadienyl, naphthyl, or heterocyclyl, R2 is H, halogen, OH, alkyl, aminoalkyl, alkylaminoalkyl , dialkoylaminoalkyl, alkyloxy, alkylthio, acyloxy, carboxy, optionally substituted alkyloxycarbonyl, benzyloxycarbonyl, amino or acylamino, and n is 0, 1 or 2, in their stereoisomeric forms and their mixtures, optionally their salts when they exist and their preparation. The new derivatives according to the invention are particularly advantageous as antagonists of substance P. (CF DRAWING IN BOPI) |