| abstract |
Compounds of general formulas (CF DRAWING IN BOPI) in which X = bond, oxygen, sulfur, OCH2, CH2 O, CO, R1 = alkyl, alkenyl or cycloalkylalkyl, R2 = hydrogen, alkyl, alkenyl, alkynyl, aryl, arylalkyl, aryloxyalkyl , arylthioalkyl, cycloalkylalkyl, or heteroarylalkyl, R3 = CO2 H, SO3 H, PO3 H, 1H- tetrazol-5-yl, NHCOR1 1, NHSO2 R1 1, CONHSO2 R1 1, CONHOR1 2, CONH-heteroaryl or SO2 NH-heteroaryl, where R1 1 = methyl, trifluoromethyl or phenyl R1 2 = hydrogen, methyl or phenyl, and heteroaryl = heterocycle of formulas (a) or (b) (CF DRAWING IN BOPI) in which R1 3 = hydrogen, methyl or phenyl, R1 4 = hydrogen or trifluoromethyl, and Z = oxygen, sulfur, or NR1 3, R1 3 being as defined above, as well as their pharmaceutically acceptable organic or inorganic salts. Application in therapy. |