| abstract |
The subject of the invention is novel polypeptides having dopaminergic receptor activity containing :. the sequence of 400 amino acids in Figure 1,. or a fragment of this sequence, this fragment being such that * either it nevertheless contains the sites contained in this sequence and whose presence is necessary so that, when this fragment is exposed on the surface of a cell, it is capable of binding dopamine, its agonists or antagonists in a specific and measurable manner, for example by means of a radioactive ligand, * either it is likely to be recognized by antibodies which also recognize the aforesaid sequence of 400 amino acids, but neither recognize nor the dopaminergic D-1 receptor, neither the dopaminergic D-2 receptor, nor the rat D-3 receptor, * either it is capable of generating antibodies recognizing the aforesaid sequence of 446 amino acids but not recognizing the dopaminergic receptor D- 1, neither the dopaminergic D-2 receptor, nor the rat D-3 receptor. |