| abstract |
Amino-4-methyl-1 tetralin derivatives of general formula (I) in which X represents an aromatic ring, in particular phenyl, naphthyl, alpha or beta-thienyl, which may bear one or two substituents chosen from halo, hydroxy, alkoxy in C1 to C8, trifluoromethyl; R1 represents a hydrogen atom or a halogen, a hydroxy group, a C1 to C8 alkoxy group, a linear or branched C1 to C4 alkyl group optionally halogenated, occupying one of positions 5, 6 or 7, or else a methylenedioxy group occupying the 5 and 6 or 6 and 7 positions; R2 represents a hydrogen or halogen atom, a hydroxy group, a C1 to C8 alkoxy group, a linear or branched C1 to C4 alkyl group optionally halogenated, occupying one of the other 5, 6 or 7 positions; and R3 and R4 each represent a hydrogen atom, a linear or branched C1 to Cn alkyl group, n being 2 or more, optionally halogenated, hydroxylated or amine, or alternatively R3 and R4, taken together with the atom of nitrogen to which they are attached form a saturated heterocycle, optionally substituted, with five or six atoms, one or two of which are heteroatoms chosen from nitrogen, oxygen or sulfur. The invention also relates to the preparation of these compounds of formula (I) and their application as a medicament. (CF DRAWING IN BOPI) |