| abstract |
New process for the preparation of microspheres of fatty substances, non-soluble in water, loaded or not loaded with an active substance. This new process is characterized by the dissolution of at least one fatty substance chosen from aliphatic alcohols having from 8 to 16 carbon atoms, aliphatic acids having from 11 to 15 carbon atoms and esters thereof or their mixtures. , optionally with an active substance, in a water-miscible solvent which can also dissolve said active substance, followed by the introduction, preferably by injection using a syringe, of this mixture in an aqueous medium under stirring and at a temperature between 4 ° C and the melting point of the fatty substance (s) chosen and by recovering and drying the microspheres thus obtained. Use of the microspheres obtained according to the process in compositions for therapeutic or cosmetic use. |