| abstract |
The invention relates to compounds of formula: (CF DRAWING IN BOPI) in which: - m is 1 to 3; - Ar and Ar 'represent in particular a thienyl-2 or thienyl-3 or phenyl group; - Ar "represents an aromatic or heteroaromatic group; - X represents H; - X" represents H, OH or is joined to X "to form a carbon-carbon bond; - or X and X ', together, form an oxo or dialkylaminoalkyl-oxyimino group of formula = NO- (CH2) p -Am, where p is 2 or 3 and Am is a dialkylamino group, each alkyl being C1 -C4 ; - Y represents a nitrogen atom or a group C (X ") where X" is hydrogen or, with X ', forms a carbon-carbon bond; - Q represents hydrogen, a C1 -C4 alkyl group or an aminoalkyl group of formula - (CH2) q -Am ', where q is 2 or 3 and Am' is a piperidino, benzyl-4 piperidino or dialkylamino group; - R represents hydrogen, a methyl group or a (CH2) n -L group, where n is a number from 2 to 6 and L is hydrogen or an amino group; (CF DRAWING IN BOPI) W being an oxygen or sulfur atom or one of its salts with mineral or organic acids, as well as their process for obtaining and their use in compositions for therapeutic use in pathological phenomena involving the neurokinin system. |