| abstract |
The invention relates to a process for the preparation of thienotriazolodiazepine derivatives of general formula A (DRAWING CF IN BOPI) in which Y represents oxygen or sulfur and R represents various substituents, which consists in reacting the compound thieno-triazolo-diazepine of formula B (CF DRAWING IN BOPI) on the derivative RSCH2 COOH, then reacting the resulting compound with hydrazine hydrate, and finally cyclizing the compound thus obtained with thiorthoacetate to obtain the compound of formula A in which Y represents oxygen and, optionally, carry out a sulfurization reaction to obtain the corresponding compound of formula A in which Y represents a sulfur atom. |