| abstract |
Penam derivative represented by the following general formula or a salt thereof, very effective as antibacterial agents: (CF DRAWING IN BOPI) with R ** 1 = H, amino protecting group, or acyl; R ** 2 = H or lower alkyl; R ** 3 = H, lower alkoxy, lower alkylthio or formamido; R ** 4 = protected or unprotected carboxyl or carboxylato; R = -NHR ** 5 or -NR ** 5R ** 6 (where R ** 5 and R ** 6 = protected or unprotected hydroxyl, cyano, sulfo or lower alkyl, aryl, acyl, carbamoyl, sulfamoyl, lower alkylsulfonyl or heterocyclic, substituted or not), or -N = CR ** 7R ** 8 (where R ** 7 and R ** 8 = H or carboxyl, protected or not, cyano or lower alkyl, lower alkenyl, lower alkynyl, aryl , amino, acyl, acyloxy, carbamoyl, carbamoyloxy, sulfamoyl, lower alkylthio, ureido or heterocyclic, substituted or not, or R ** 7 and R ** 8 can form a cycloalkene or heterocyclic ring with the C atom to which R ** 7 and R ** 8 are attached); and n = 1 or 2. |