| abstract |
The invention relates to a method for the preparation of microcapsules providing direct compression of a drug into tablets and rapid release of the drug as an active ingredient from the tablets, which comprises microencapsulating the crystalline granules of insoluble active ingredients. in cyclohexane having a particle size equal to at most 1000 mum, preferably less than 60 mum and more preferably less than 30 mum, in a cyclohexane-based medium with ethylcellulose admitted in an amount of 1:30 at 1:15, preferably 1:20 to 1:10, based on the core substance, if desired, in the presence of 0.001 to 1.0% w / v, preferably 0.01 to 0.05% by weight / volume, of an anionic surfactant; or post-treating the microencapsulated drug granules with ethylcellulose with a surfactant dissolved in cyclohexane and admitted in an amount of 0.001 to 1.0% w / v, preferably 0.1 to 0, 5% w / v, based on cyclohexane. |