| abstract |
The invention relates to the preparation of transition metal complexes, for example technetium or rhenium, which can be used as radiopharmaceuticals. For this preparation, an oxygen-containing compound of the transition metal, for example an ammonium or alkali metal pertechnetate or perrhenate, is preferably reacted in aqueous solution with a first ligand chosen from the group of aliphatic and aromatic phosphines and polyphosphines. , and a second nitrogenous ligand consisting of a pharmaceutically acceptable metal azide. The complex obtained has an M = N part with M representing the transition metal. It can be used as it is as a radiopharmaceutical or alternatively serve as an intermediate for preparing other radiopharmaceuticals by exchange reaction with a third ligand, a monoclonal antibody or an antibody fragment. |