http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2622108-A1

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filingDate 1987-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab04eb41b307c1e23926715c317f510e
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publicationDate 1989-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber FR-2622108-A1
titleOfInvention PREPARATION OF PROCONVERTINE CONCENTRATES (FACTOR VII), ANTIHEMOPHILIC FACTOR B (FACTOR IX) AND OTHER PLASMA PROTEINS, AND THEIR THERAPEUTIC USE
abstract The invention relates to a process for the preparation of plasma derivatives. According to this process, a human cryoprecipitate supernatant is subjected to chromatography on anion exchange resin in the presence of heparin and a filtrate containing antithrombin III, immunoglobulins and albumin is separated and by increasing the ionic strength. of the buffer, four fractions enriched respectively with alpha-1-antitrypsin (AAT), proconvertin (Factor VII), proteins C and S and inhibitory inter-alpha-trypsin, and, finally, antihemophilic factor B (Factor IX). This process makes it possible to obtain, in significant yields, high purity proconvertin and Factor IX concentrates which are perfectly suitable for their therapeutic use.
priorityDate 1987-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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