| abstract |
COMPOUNDS OF FORMULA (CF DRAWING IN BOPI) INCLUDING ALL THEIR STEREO-ISOMERS, FORMULA IN WHICH A IS -CHCH- OR - (CH) 2-; M IS A NUMBER FROM 0 TO 10; R IS A LOWER ALKYL, ARYL, ARALKYL OR LOWER ALKENYL RADICAL; R IS AN ATOM OF HYDROGEN OR A LOWER RADICAL ALKYL, ARYL, ARALKYL, LOWER ALCENYL, CYCLOALKYL, ALKANOYL OR AROYL; P IS A NUMBER FROM 1 TO 5; Y IS O OR (O) Q OR Q IS EQUAL TO 0.1 OR 2; AND R IS A RADICAL LOWER ALKYL, ARYL, ARYLALKYL, CYCLOALKYL, CYCLOALKYLALKYL, LOWER ALCENYL OR LOWER ALCYNYL, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF. THESE COMPOUNDS ARE INHIBITORS OF PROSTAGLANDIN AND LEUCOTRIAN BIOSYNTHESIS AND AS SUCH, CAN BE USED, FOR EXAMPLE, AS ANTI-ALLERGIC AND ANTI-INFLAMMATORY AGENTS AND ALSO AS ANTIPSORIASIS AGENTS. |